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For patients carrying primarily visceral fat, tesamorelins clinical evidence for VAT reduction is strong

Furthermore, most studies prioritize symptom improvement (e.g., pain reduction) as endpoints, with a pronounced lack of robust evidence demonstrating structural modification (e.g., cartilage preservation via quantitative MRI)

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For individuals with atrophic gastritis, pernicious anaemia, or those taking proton pump inhibitors , food-bound B12 absorption is already compromised

This suggests that IGF-1 increased glutamate release at presynaptic sites or the functional excitability of synaptic contacts, but had no effect on non-NMDA or NMDA receptors